Karakterisasi senyawa kompleks dengan logam transisi pada mikropartikel bunga cempaka (Magnolia champaca (L.) Baill. Ex Pierre) sebagai kandidat potensial nutrasetikal
Characterization of complex compounds with transition metals on microparticles of cempaka flowers (Magnolia champaca (L.) Baill. Ex Pierre) as a potential nutraceutical candidate
Abstract
The components of complex compounds containing transition metals play a significant role in regulating the nutraceutical ability for disease prevention and treatment. The bonding of complex molecules with transition metals allows energy to be transferred between complex compounds that enter the body and systems within the body. The aim of this research was to investigate the composition of complex chemical components including transition metals used in the processing of M. champaca flowers for potential nutraceuticals. Transition metal identification (XRF), compound identification (LC-MS), functional group identification (FTIR), crystal character identification (XRD), particle surface morphology identification (SEM), particle size identification (PSA), and identification of physicochemical characters of Niacin complex with transition metals (SwissADME) are among the stages of the study. The results showed that the highest type of transition metal was Fe, containing to 0.42%, Niacin group compounds identified were Nicotinic acid and Nicotinamide, in the region 505 - 405 cm-1, there is a transition metal bond with a Fe (Fe - O) functional group, solid particles in M. champaca microparticles were amorphous, peak peaks at an angle of 2ɵ 19,83°, Particle morphology is similar to powder on its surface, particles measuring 208.20 µm. The physicochemical properties of the Niacin complex with transition metals demonstrate that niacin group chemicals have different effects on nicotinic acid and nicotinamide. These complex chemicals are generally easily absorbed by body systems. Since the synthesis of niacin complexes with transition metals has improved physicochemical properties, it could be employed as a possible nutraceutical candidate.
References
Abascal, K., Ganora, L., & Yarnell, E. (2005). The effect of freeze‐drying and its implications for botanical medicine: a review. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 19(8), 655-660. https://doi.org/10.1002/ptr.1651
Al-Saeedi, S. I., Al-Senani, G. M., Abd-Elkader, O. H., & Deraz, N. M. (2021). One pot synthesis, surface and magnetic properties of Cu2O/Cu and Cu2O/CuO nanocomposites. Crystals, 11(07), 751.
Al-Saif, F. A., & Refat, M. S. (2012). Ten metal complexes of vitamin B3/niacin: Spectroscopic, thermal, antibacterial, antifungal, cytotoxicity and antitumor studies of Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Pd(II), Cd(II), Pt(IV) and Au(III) complexes. Journal of Molecular Structure, 1021, 40–52. https://doi.org/https://doi.org/10.1016/j.molstruc.2012.04.057
Altomare, A., Cuocci, C., Giacovazzo, C., Moliterni, A., & Rizzi, R. (2008). QUALX: a computer program for qualitative analysis using powder diffraction data. Journal of Applied Crystallography, 41(4), 815-817. https://doi.org/10.1107/S0021889808016956
Anand, S., & Bharadvaja, N. (2022). Potential Benefits of Nutraceuticals for Oxidative Stress Management. Revista Brasileira de Farmacognosia, 32(2), 211–220. https://doi.org/10.1007/s43450-022-00246-w
Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific reports, 7(1), 42717, 1–13. https://doi.org/10.1038/srep42717
Faramayuda, F., Permana, J., Syam, A. K., & Elfahmi, E. (2021). Identification of secondary metabolites from callus piper retrofractum vahl. Elkawnie: Journal of Islamic Science and Technology, 7(1), 197-214. https://doi.org/10.22373/ekw.v7i1.8630
Fazary, A. E., Ju, Y. H., Rajhi, A. Q., Alshihri, A. S., Alfaifi, M. Y., Alshehri, M. A., Saleh, K. A., Elbehairi, S. E. I., Fawy, K. F., & Abd-Rabboh, H. S. M. (2016). Bioactivities of Novel Metal Complexes Involving B Vitamins and Glycine. Open Chemistry, 14(1), 287–298. https://doi.org/10.1515/chem-2016-0028
Galani, A., Efthimiadou, E. K., Theodosiou, T., Kordas, G., & Karaliota, A. (2014). Novel levofloxacin zinc (II) complexes with N-donor heterocyclic ligands, as potential fluorescent probes for cell imaging: synthesis, structural characterization and in vitro cytotoxicity. Inorganica Chimica Acta, 423, 52-59. https://doi.org/10.1016/j.ica.2014.09.034
Gondokesumo, M. E., Pardjianto, B., Sumitro, S. B., Widowati, W., & Handono, K. (2019). Xanthones analysis and antioxidant activity analysis (Applying ESR) of six different maturity levels of mangosteen rind extract (Garcinia mangostana Linn.). Pharmacognosy Journal, 11(2), 369–373. https://doi.org/10.5530/pj.2019.11.56
Han, X., Wu, M. Q., Yang, Z. R., Zhang, D. K., Mao, Y., Han, J., ... & Xiao, X. H. (2016). comprehensive evaluation of powdered chinese herbal medicines-an exemplification of isatidis radix. Chinese Herbal Medicines, 8(3), 286-292. https://doi.org/10.1016/S1674-6384(16)60052-7
Handayani, L., Suharmiati, S., Sakirno, S., Djoerban, B., Soegijono, K. R., & Pranata, S. (1998). Inventarisasi Jamu Madura yang dimanfaatkan untuk pengobatan atau perawatan gangguan kesehatan berkaitan dengan fungsi reproduksi wanita. Buletin Penelitian Sistem Kesehatan, 2(1), 40-49. https://doi.org/10.22435/bpsk.v2i1Feb.1568
Hasan, M. M., Hossain, M. E., Halim, M. E., & Ehsan, M. Q. (2015). Preparation and characterisation of some transition metal complexes of niacinamide (Vitamin B3). Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences, 58(2), 59-65.
Hitayezu, E., & Kang, Y. H. (2021). Effect of particle size on the physicochemical and morphological properties of Hypsizygus marmoreus mushroom powder and its hot-water extracts. Korean Journal of Food Preservation, 28(4), 540–549. https://doi.org/10.11002/KJFP.2021.28.4.540
Jha, S. K., Roy, P., & Chakrabarty, S. (2021). Nutraceuticals with pharmaceutics : Its importance and their applications. International Journal of Drug Development and Research, 13(S3), 1-10.
Joshi, D. D. (2012). Herbal drugs and fingerprints: evidence based herbal drugs. Springer Science & Business Media. https://doi.org/10.1007/978-81-322-0804-4_1
Jovanović, A. A., Lević, S. M., Pavlović, V. B., Marković, S. B., Pjanović, R. V., Đorđević, V. B., ... & Bugarski, B. M. (2021). Freeze vs. Spray drying for dry wild thyme (Thymus serpyllum L.) extract formulations: The impact of gelatin as a coating material. Molecules, 26(13), 3933. https://doi.org/10.20944/preprints202105.0358.v1
Jurca, T., Marian, E., Vicaş, L. G., Mureşan, M. E., & Fritea, L. (2017). Metal complexes of pharmaceutical substances. Spectroscopic Analysis, 123.
Jyothi, R., Yaligar ICAR -Krishi Vigyan Kendra, R., Jyothi ICAR -Krishi Vigyan Kendra, I. R., Narappa ICAR -Krishi Vigyan Kendra, I. G., Ravi ICAR -Krishi Vigyan Kendra, I. M., & Yaligar, R. (2020). Swiss ADME prediction of phytochemicals present in Butea monosperma (Lam.) Taub. Journal of Pharmacognosy and Phytochemistry, 9(3), 1799-1809.
Kanwal, S., Iqbal, A., & Ahmad, W. (2017). Cu and Mn complexes of nicotinic acid and imidazole: a current review. International Journal Advanced Research, 5(4), 1350-1368. https://doi.org/10.21474/IJAR01/3959
Khan, R. A., Elhassan, G. O., & Qureshi, K. A. (2014). Nutraceuticals: In the treatment & prevention of diseases –an overview. The Pharma Innovation Journal, 3(10), 47–50.
Larkin, P. J. (2017). Infrared and raman spectroscopy: principles and spectral interpretation. In Infrared and Raman Spectroscopy: Principles and Spectral Interpretation.
Mehta, B. K., Chhajlani, M., & Shrivastava, B. D. (2017, April). Green synthesis of silver nanoparticles and their characterization by XRD. In Journal of physics: conference series (Vol. 836, No. 1, p. 012050). IOP Publishing. https://doi.org/10.1088/1742-6596/836/1/012050
Mohamed, E., Mohsen, J., & Salih, N. A. (2021). Nicotinic acid derivatives: application and uses, review synthesis organic view project. Journal of Research in Chemistry, 2(2), 51–56. https://doi.org/10.22271/reschem
Nakamoto, K. (2006). Infrared and raman spectra of inorganic and coordination compounds. Handbook of Vibrational Spectroscopy.
Panel, E., & Nda, A. (2013). Scientific opinion on dietary reference values for niacin. EFSA Journal, 11(8), 1–39. https://doi.org/10.2903/j.efsa.2013.3332
Phunde, R. D., Chikurte, S. N., Patil, P. A., & Chokhar, S. (2019). Avaleha kalpana-a review. Journal of Ayurveda and Integrated Medical Sciences, 4(3), 89-91.
Raja, S., & Koduru, R. (2014). A complete profile on Michelia champaca-traditional uses, pharmacological activities and phytoconstituents. International Journal for Pharmaceutical Research Scholars, 3(2), 496-504.
Sabry, R. S., & Alkareem, R. A. S. A. (2018). Synthesis of ZnO-CuO flower-like hetero-nanostructures as volatile organic compounds (VOCs) sensor at room temperature. Materials Science- Poland, 36(3), 452–459. https://doi.org/10.2478/msp-2018-0055
Sadat, A., & Joye, I. J. (2020). Peak fitting applied to fourier transform infrared and raman spectroscopic analysis of proteins. Applied Sciences, 10(17), 5918. https://doi.org/10.3390/app10175918
Sciences, A. (2019). SwissADME predictions of pharmacokinetics and drug-likeness properties of small molecules present in Ipomoea mauritiana Jacq. Journal of Pharmacognosy and Phytochemistry, 8(5), 2063-2073.
Sholikhah, E. N. (2016). Indonesian medicinal plants as sources of secondary metabolites for the pharmaceutical industry. Journal of Thee Medical Sciences (Berkala Ilmu Kedokteran), 48(04), 226–239. https://doi.org/10.19106/jmedsci004804201606
Singh, V., Feldman, Y., Leitus, G., Brumfeld, V., Shimon, L., Lahav, M., & van der Boom, M. E. (2023). Factors controlling complex morphologies of isomorphous metal‐organic frameworks. Chemistry – A European Journal, 29(54). 202301825. https://doi.org/10.1002/chem.202301825
Sousa, C., Moutinho, C., Vinha, A. F., & Matos, C. (2019). Trace minerals in human health: Iron, zinc, copper, manganese and fluorine. International Journal of Science and Research Methodology, 13(3), 57-80.
State, B. (2018). Synthesis and characterization of Cu (II) complexes of salicylate ligands. Journal of Applied Sciences and Environmental Management, 22(12), 1961-1964.
Tripathi, P., Ghosh, S., & Talapatra, S. N. (2019). Bioavailability prediction of phytochemicals present in Calotropis procera (Aiton) R. Br. by using Swiss-ADME tool. World Scientific News, (131), 147-163.
Wahyudi, A. S. and S. R. (2011). Preliminary study of particle size measurement of fine phosphate rocks using dynamic light scattering method. JournalIndonesian Mining, 14(3), 115–122.
Widjonarko, N. E. (2016). Introduction to advanced X-ray diffraction techniques for polymeric thin films. Coatings, 6(4), 1-17. https://doi.org/10.3390/coatings6040054
Zhao, L., Duan, X., Cao, W., Ren, X., Ren, G., Liu, P., & Chen, J. (2021). Effects of different drying methods on the characterization, dissolution rate and antioxidant activity of ursolic acid-loaded chitosan nanoparticles. Foods, 10(10), 1-11.
Copyright (c) 2023 Khoirin Maghfiroh, Deny Utomo
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors send the manuscript with the understanding that if accepted for publication, the copyright of the article belongs to the authors and retains publishing rights without restriction. More...